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This process may be artificially induced by somatic cell nuclear transfer (SCNT), cell fusion and also now, viral transduction with four stem cell genes.

Each of the three strategies can drive a pluripotent stem cell, which can maintain self-renewal and develop into any type of tissues or cells in the body.

Changes in the epigenome, represented by histone post-translational modification (h PTM) have been implicated in the abnormal nuclear reprogramming in the soma that is manifest in cancer, but the exact mechanism by which this occurs is unknown.

In addition, the mechanisms that alter the epigenome in the normal nuclear reprogramming in the germline during sexual reproduction, the keystone to understanding the mechanism of cancer formation, is still largely unexplored due to the multicellular complexity of the human body, in which the germline and somatic cells are spatially isolated from each other.

My study investigates the fundamental mechanism that commits the germline to nuclear reprogramming and the consequent somatic death using the ciliate protozoan Tetrahymena thermophila as model biology system.

The most significant advantage of the organism in this aim is that it maintains stably differentiated germline and somatic nuclear genomes in a single cytoplasm, without a cell membrane boundary.

These strategies could provide a potentially endless source of cells for biological research as well as medical applications, toxicity assessment, drug testing and possibly even gene therapy.

If your browser does not accept cookies, you cannot view this site.In fact, the nucleus of an intestinal cell from a tadpole, when inserted into an enucleated frog egg, was able to support development all the way to a mature frog.The process by which factors present in egg cytoplasm change the patterns of gene expression from those of a differentiated cell nucleus to those of an undifferentiated cell nucleus is called reprogramming.The ES cells produced by SCNT retained their self-renewal and pluripotent capabilities, contributing to all germ cell layers.Gene expression profiling experiments showed that the ES cell lines derived from NT and fertilized mouse blastocysts were indistinguishable.

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